LymphedemaV1, Main, Exploration, bibRecord, 004B94

Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

Identifieur interne : 004B94 ( Main/Exploration ); précédent : 004B93; suivant : 004B95

Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

Auteurs : Chandanapurath Shiny [Inde] ; Nagampalli S. A. Krushna [Inde] ; Subash Babu [Inde] ; S. Elango [Inde] ; Guruswamy Manokaran [Inde] ; Rangarajan Badri Narayanan [Inde]

Source :

Microbes and infection / Institut Pasteur [ 1286-4579 ] ; 2011.

RBID : PMC:3515687

Descripteurs français

KwdFr :
- Activation des lymphocytes (), Adolescent, Adulte, Animaux, Antigène CTLA-4 (immunologie), Brugia malayi (immunologie), Brugia malayi (microbiologie), Cellules cultivées, Chaperonine-60 (génétique), Chaperonine-60 (immunologie), Chaperonine-60 (pharmacologie), Enfant, Facteur de croissance transformant bêta (biosynthèse), Facteur de croissance transformant bêta (immunologie), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Humains, Immunomodulation (), Interféron gamma (biosynthèse), Interféron gamma (immunologie), Interleukine-10 (biosynthèse), Interleukine-10 (immunologie), Lymphocytes T régulateurs (), Lymphocytes T régulateurs (immunologie), Mâle, Protéines bactériennes (génétique), Protéines bactériennes (immunologie), Protéines bactériennes (pharmacologie), Protéines recombinantes (génétique), Protéines recombinantes (immunologie), Protéines recombinantes (pharmacologie), Sous-unité alpha du récepteur à l'interleukine-2 (immunologie), Symbiose, Wolbachia (), Wolbachia (physiologie).
MESH :
- biosynthèse : Facteur de croissance transformant bêta, Interféron gamma, Interleukine-10.
- génétique : Chaperonine-60, Protéines bactériennes, Protéines recombinantes.
- immunologie : Antigène CTLA-4, Brugia malayi, Chaperonine-60, Facteur de croissance transformant bêta, Filariose lymphatique, Interféron gamma, Interleukine-10, Lymphocytes T régulateurs, Protéines bactériennes, Protéines recombinantes, Sous-unité alpha du récepteur à l'interleukine-2.
- microbiologie : Brugia malayi.
- parasitologie : Filariose lymphatique.
- pharmacologie : Chaperonine-60, Protéines bactériennes, Protéines recombinantes.
- physiologie : Wolbachia.
- Activation des lymphocytes, Adolescent, Adulte, Animaux, Cellules cultivées, Enfant, Femelle, Humains, Immunomodulation, Lymphocytes T régulateurs, Mâle, Symbiose, Wolbachia.

English descriptors

KwdEn :
- Adolescent, Adult, Animals, Bacterial Proteins (genetics), Bacterial Proteins (immunology), Bacterial Proteins (pharmacology), Brugia malayi (immunology), Brugia malayi (microbiology), CTLA-4 Antigen (immunology), Cells, Cultured, Chaperonin 60 (genetics), Chaperonin 60 (immunology), Chaperonin 60 (pharmacology), Child, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Female, Humans, Immunomodulation (drug effects), Interferon-gamma (biosynthesis), Interferon-gamma (immunology), Interleukin-10 (biosynthesis), Interleukin-10 (immunology), Interleukin-2 Receptor alpha Subunit (immunology), Lymphocyte Activation (drug effects), Male, Recombinant Proteins (genetics), Recombinant Proteins (immunology), Recombinant Proteins (pharmacology), Symbiosis, T-Lymphocytes, Regulatory (drug effects), T-Lymphocytes, Regulatory (immunology), Transforming Growth Factor beta (biosynthesis), Transforming Growth Factor beta (immunology), Wolbachia (chemistry), Wolbachia (physiology).
MESH :
- chemical , biosynthesis : Interferon-gamma, Interleukin-10, Transforming Growth Factor beta.
- chemical , genetics : Bacterial Proteins, Chaperonin 60, Recombinant Proteins.
- chemical , immunology : Bacterial Proteins, CTLA-4 Antigen, Chaperonin 60, Interferon-gamma, Interleukin-10, Interleukin-2 Receptor alpha Subunit, Recombinant Proteins, Transforming Growth Factor beta.
- chemical , pharmacology : Bacterial Proteins, Chaperonin 60, Recombinant Proteins.
- chemistry : Wolbachia.
- drug effects : Immunomodulation, Lymphocyte Activation, T-Lymphocytes, Regulatory.
- immunology : Brugia malayi, Elephantiasis, Filarial, T-Lymphocytes, Regulatory.
- microbiology : Brugia malayi.
- parasitology : Elephantiasis, Filarial.
- physiology : Wolbachia.
- Adolescent, Adult, Animals, Cells, Cultured, Child, Female, Humans, Male, Symbiosis.

Abstract

Wolbachia, an endosymbiont present in filarial nematodes, have been implicated in a variety of roles, including the worm development and survival. Elucidation of the role of Wolbachia in filarial nematode biology and pathogenesis has become the focus of many studies and its contribution to parasite survival or immune response is still unclear. Recombinant Wolbachia HSP60 decreases T cell activation and lymphoproliferation in filarial infected people compared to endemic controls as observed by the assessment of T cell activation markers and cytokine responses in the peripheral blood mononuclear cells. Reduced T cell activation may be linked to T regulatory cell activity since it is associated with increased expression of CTLA4 and CD25 on CD4⁺ T cells in filarial infected group upon stimulation with recombinant Wolbachia HSP60. In addition, elevated interleukin-10 and TGF-β cytokines corroborate the reduced CD4⁺ T cell activation and interferon-γ observed upon recombinant Wolbachia HSP60 stimulation in filarial patients. Hence, these findings indicate that Wolbachia HSP60 may also contribute to the immune modulation seen in filarial patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515687

DOI: 10.1016/j.micinf.2011.07.004
PubMed: 21827871
PubMed Central: 3515687

Affiliations:

Inde

Le document en format XML

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 heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis</title>
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 heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Bacterial Proteins (genetics)</term>
<term>Bacterial Proteins (immunology)</term>
<term>Bacterial Proteins (pharmacology)</term>
<term>Brugia malayi (immunology)</term>
<term>Brugia malayi (microbiology)</term>
<term>CTLA-4 Antigen (immunology)</term>
<term>Cells, Cultured</term>
<term>Chaperonin 60 (genetics)</term>
<term>Chaperonin 60 (immunology)</term>
<term>Chaperonin 60 (pharmacology)</term>
<term>Child</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunomodulation (drug effects)</term>
<term>Interferon-gamma (biosynthesis)</term>
<term>Interferon-gamma (immunology)</term>
<term>Interleukin-10 (biosynthesis)</term>
<term>Interleukin-10 (immunology)</term>
<term>Interleukin-2 Receptor alpha Subunit (immunology)</term>
<term>Lymphocyte Activation (drug effects)</term>
<term>Male</term>
<term>Recombinant Proteins (genetics)</term>
<term>Recombinant Proteins (immunology)</term>
<term>Recombinant Proteins (pharmacology)</term>
<term>Symbiosis</term>
<term>T-Lymphocytes, Regulatory (drug effects)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>Transforming Growth Factor beta (biosynthesis)</term>
<term>Transforming Growth Factor beta (immunology)</term>
<term>Wolbachia (chemistry)</term>
<term>Wolbachia (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes ()</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Animaux</term>
<term>Antigène CTLA-4 (immunologie)</term>
<term>Brugia malayi (immunologie)</term>
<term>Brugia malayi (microbiologie)</term>
<term>Cellules cultivées</term>
<term>Chaperonine-60 (génétique)</term>
<term>Chaperonine-60 (immunologie)</term>
<term>Chaperonine-60 (pharmacologie)</term>
<term>Enfant</term>
<term>Facteur de croissance transformant bêta (biosynthèse)</term>
<term>Facteur de croissance transformant bêta (immunologie)</term>
<term>Femelle</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Humains</term>
<term>Immunomodulation ()</term>
<term>Interféron gamma (biosynthèse)</term>
<term>Interféron gamma (immunologie)</term>
<term>Interleukine-10 (biosynthèse)</term>
<term>Interleukine-10 (immunologie)</term>
<term>Lymphocytes T régulateurs ()</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Mâle</term>
<term>Protéines bactériennes (génétique)</term>
<term>Protéines bactériennes (immunologie)</term>
<term>Protéines bactériennes (pharmacologie)</term>
<term>Protéines recombinantes (génétique)</term>
<term>Protéines recombinantes (immunologie)</term>
<term>Protéines recombinantes (pharmacologie)</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2 (immunologie)</term>
<term>Symbiose</term>
<term>Wolbachia ()</term>
<term>Wolbachia (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-gamma</term>
<term>Interleukin-10</term>
<term>Transforming Growth Factor beta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term>
<term>Chaperonin 60</term>
<term>Recombinant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Bacterial Proteins</term>
<term>CTLA-4 Antigen</term>
<term>Chaperonin 60</term>
<term>Interferon-gamma</term>
<term>Interleukin-10</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
<term>Recombinant Proteins</term>
<term>Transforming Growth Factor beta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Bacterial Proteins</term>
<term>Chaperonin 60</term>
<term>Recombinant Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Facteur de croissance transformant bêta</term>
<term>Interféron gamma</term>
<term>Interleukine-10</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Wolbachia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunomodulation</term>
<term>Lymphocyte Activation</term>
<term>T-Lymphocytes, Regulatory</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chaperonine-60</term>
<term>Protéines bactériennes</term>
<term>Protéines recombinantes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigène CTLA-4</term>
<term>Brugia malayi</term>
<term>Chaperonine-60</term>
<term>Facteur de croissance transformant bêta</term>
<term>Filariose lymphatique</term>
<term>Interféron gamma</term>
<term>Interleukine-10</term>
<term>Lymphocytes T régulateurs</term>
<term>Protéines bactériennes</term>
<term>Protéines recombinantes</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term>
<term>Elephantiasis, Filarial</term>
<term>T-Lymphocytes, Regulatory</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Brugia malayi</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Brugia malayi</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chaperonine-60</term>
<term>Protéines bactériennes</term>
<term>Protéines recombinantes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Wolbachia</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Wolbachia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Cells, Cultured</term>
<term>Child</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Symbiosis</term>
</keywords>
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<term>Adolescent</term>
<term>Adulte</term>
<term>Animaux</term>
<term>Cellules cultivées</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunomodulation</term>
<term>Lymphocytes T régulateurs</term>
<term>Mâle</term>
<term>Symbiose</term>
<term>Wolbachia</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Wolbachia</italic>
, an endosymbiont present in filarial nematodes, have been implicated in a variety of roles, including the worm development and survival. Elucidation of the role of <italic>Wolbachia</italic>
 in filarial nematode biology and pathogenesis has become the focus of many studies and its contribution to parasite survival or immune response is still unclear. Recombinant <italic>Wolbachia</italic>
 HSP60 decreases T cell activation and lymphoproliferation in filarial infected people compared to endemic controls as observed by the assessment of T cell activation markers and cytokine responses in the peripheral blood mononuclear cells. Reduced T cell activation may be linked to T regulatory cell activity since it is associated with increased expression of CTLA4 and CD25 on CD4<sup>+</sup>
 T cells in filarial infected group upon stimulation with recombinant <italic>Wolbachia</italic>
 HSP60. In addition, elevated interleukin-10 and TGF-β cytokines corroborate the reduced CD4<sup>+</sup>
 T cell activation and interferon-γ observed upon recombinant <italic>Wolbachia</italic>
 HSP60 stimulation in filarial patients. Hence, these findings indicate that <italic>Wolbachia</italic>
 HSP60 may also contribute to the immune modulation seen in filarial patients.</p>
</div>
</front>
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</noRegion>
<name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<name sortKey="Elango, S" sort="Elango, S" uniqKey="Elango S" first="S." last="Elango">S. Elango</name>
<name sortKey="Krushna, Nagampalli S A" sort="Krushna, Nagampalli S A" uniqKey="Krushna N" first="Nagampalli S. A." last="Krushna">Nagampalli S. A. Krushna</name>
<name sortKey="Manokaran, Guruswamy" sort="Manokaran, Guruswamy" uniqKey="Manokaran G" first="Guruswamy" last="Manokaran">Guruswamy Manokaran</name>
<name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name>
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</affiliations>
</record>

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EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004B94 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004B94 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3515687
   |texte=   Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:21827871" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.